Effect of hyaluronic acid on the struvite crystallization: A structural, morphological, and thermal analysis study

The struvite crystals constitute one of the common types urinary stones. Such stones are also referred as “infection stones” due to their tendency cause infections in tract. A considerable effort has been placed identify natural or synthetic crystal-growth modifiers for this kind stone literature, yet macromolecules commonly found urine have underexplored. In present study, we experimentally focus on how hyaluronic acid, a protein urine, alters crystallization aqueous solution and an artificial media. By gradually adding ammonium dihydrogen phosphate containing magnesium chloride hexahydrate, reactive is carried out well-mixed thermostated vessel at 37 °C. resulting characterized structurally by XRD FTIR well morphologically terms surface charge. addition, thermal decomposition behavior with without acid released volatile products were simultaneously investigated using TGA/FTIR system. average activation energy calculated Friedman method was 49.2 ± 5.1 kJ/mol. results kinetic thermodynamic analyses showed that endothermic followed multiple stage reaction mechanism.